The present work was to design and evaluation of mouth dissolving tablets of Loratadine by using with different concentration of different super disintegrants. The Drug and excipient were characterized using differential scanning calorimetry (DSC) and automated total reflectance spectrometer (ATR). The drug excipient blend was evaluated for examined physiochemical properties. The prepared tablets were evaluated for thickness, hardness, friability, wetting time, water absorption ratio, content uniformility, in-vitro disintegration time and in-vitro dissolution studies. Formulation (F-1) show quick disintegration time of 15.26 s, which is very charterstics of mouth dissolving tablet and formulation (F-1) were subjected to accelerated stability studies for 3 months at temperature 40±5°C/75±5% RH. The tested did not show any change with respect to taste, disintegration and dissolution profile. Additionally inclusion of stevia (stevia rebidiana) leaves powder still makes the formulation 400 times sweeter then sucrose and diabetic friendly.
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